Experience XEOMIN® (incobotulinumtoxinA)

Over One Million Patients Around the World Have Experienced XEOMIN, and That Number Continues to Grow.2*

XEOMIN is the latest neurotoxin for treatment of adults with upper limb spasticity (ULS), cervical dystonia, and blepharospasm.

XEOMIN Is Well Established Worldwide

  • FDA approved in 2010 for use in the United States for cervical dystonia and blepharospasm in adults1
  • FDA approved in 2015 for use in the United States for upper limb spasticity in adults.1
  • Approved in Europe for cervical dystonia and blepharospasm since 2005 and approved for post-stroke ULS in Europe since 20092
  • Approved in Canada for cervical dystonia, blepharospasm, and ULS since 20092
  • Used in 49 countries worldwide2
  • Studied in clinical trials worldwide, which involved:
    • More than 400 adult patients with upper limb spasticity, including patients who had been previously treated and patients who were new to neurotoxin therapy2
    • Nearly 600 patients with cervical dystonia2
    • Nearly 400 patients with blepharospasm2

If you are considering XEOMIN, it’s important to be aware of the most common side effects:

  • In two clinical studies of XEOMIN for upper limb spasticity in adults, the most common side effects included:
    • Seizure
    • Nasopharyngitis (common cold)
    • Dry mouth
    • Upper respiratory tract infection
  • In a clinical study of XEOMIN for blepharospasm, the 9 most common side effects included1:
    • Drooping eyelid
    • Dry mouth
    • Dry eye
    • Visual impairment
    • Diarrhea
    • Headache
    • Difficult or labored breathing
    • Nasopharyngitis (common cold)
  • In a clinical study of XEOMIN for cervical dystonia, the 5 most common side effects included1:
    • Dysphagia
    • Injection site pain
    • Neck pain
    • Muscular weakness
    • Musculoskeletal pain


XEOMIN Can Cause Serious Side Effects

XEOMIN® may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems anytime (hours to week) after treatment with XEOMIN®:

  • Problems with swallowing, speaking, or breathing can happen within hours to weeks after an injection of XEOMIN® if the muscles that you use to breathe and swallow become weak. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment with XEOMIN®.
  • People with certain breathing problems may need to use muscles in their neck to help them breathe and may be at greater risk for serious breathing problems with XEOMIN®.
  • Swallowing problems may last for several months, and during that time you may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving XEOMIN® have the highest risk of getting these problems.
  • Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.

Please see full Prescribing Information and Medication Guide for a full description of serious side effects.

Talk to your doctor if you have any questions about the side effects of XEOMIN.


A Treatment for You

Every person’s treatment needs are different, and the therapy you and your doctor choose should reflect that. If you have been previously treated for adult upper limb spasticity, cervical dystonia, or blepharospasm, your doctor will take that into consideration when determining your initial dose of XEOMIN.

Subsequent treatment with XEOMIN is individualized by your doctor based on your condition and symptoms. That means the dose for you may not be the same as the dose for another patient with the same diagnosis.

Flexible Dosing
XEOMIN is delivered by a doctor as an intramuscular injection or series of injections. Your doctor will decide how many muscles need to be injected and the dose per muscle, and he or she may adjust that dose over time so that it is right for you. In general, XEOMIN can be used no more frequently than every 12 weeks.1

1-week onset

  • For most people, the effects of XEOMIN are typically seen within 7 days after treatment1

12-week duration

  • Effects of XEOMIN usually last about 12 weeks, but may last significantly longer or shorter in individual patients.1

Making the Switch to XEOMIN

If you have previously received neurotoxin therapy for adult upper limb spasticity, cervical dystonia, or blepharospasm, your doctor will consider your prior dose, response, and any side effects you experienced when determining if XEOMIN is right for you.1

The potency units of Xeomin are not interchangeable with other botulinum toxin products.1

Everyone is different, so you should talk to your doctor if you have any questions or concerns about your treatment process.

Learn more about XEOMIN for upper limb spasticity in adults.
Learn more about XEOMIN for cervical dystonia.
Learn more about XEOMIN for blepharospasm.

*Patients used XEOMIN for other indications in addition to cervical dystonia, blepharospasm, and upper limb spasticity in adults.


  1. XEOMIN® [package insert]. Raleigh, NC: North America, Inc; 2015.
  2. Data on file. Raleigh, NC: Merz Pharmaceuticals, LLC.