Adults with Blepharospasm

Overview Efficacy Safety Dosing

Characteristics

Second most common form of focal dystonia1

  • Causes bilateral involuntary eyelid closure, and is centrally mediated2

Reported incidence is 5 cases per million population per year worldwide2

  • Blepharospasm is thought to be underdiagnosed; the actual incidence may be significantly higher2

Blepharospasm symptoms begin insidiously and include increased blinking, tearing, a feeling of irritation, and dry eye2

Progression of symptoms is common, and may lead in severe cases to legal blindness due to inability to keep the eyes open2
Stress can worsen symptoms, and they may be partially and temporarily relieved by use of a sensory trick, such as touching a portion of the eyelid2
Symptoms may improve after sleep2

References

  1. The Epidemiological Study of Dystonia in Europe (ESDE) Collaborative Group. A prevalence study of primary dystonia in eight European countries. J Neurol. 2000;247(10):787-792.
  2. Tsui JKC. Blepharospasm and hemifacial spasm. In: Brin MF, Comella C, Jankovic K, eds. Dystonia: Etiology, Clinical Features, and Treatment. New York, NY: Lippincott Williams & Wilkins; 2004:151-158.