Using XEOMIN® Step by Step

Reconstitution and Dilution Instructions

Prior to injection, reconstitute each vial of XEOMIN with sterile, preservative-free 0.9% Sodium Chloride Injection, USP. A 20-27 gauge short-bevel needle is recommended for reconstitution. Draw up an appropriate amount of preservative-free 0.9% Sodium Chloride Injection, USP into a syringe.1

Step 1: Vial preparation1

Clean the exposed portion of the rubber stopper of the vial with alcohol (70%) prior to insertion of the needle.

Step 2: Saline injection1

After vertical insertion of the needle through the rubber stopper, the vacuum will draw the saline into the vial. Gently inject any remaining saline into the vial to avoid foam formation. If the vacuum does not pull the saline into the vial, then XEOMIN must be discarded.

Step 3: Mixing1

Remove the syringe from the vial and mix XEOMIN with the saline by carefully swirling and inverting/flipping the vial—do not shake vigorously.

Reconstituted XEOMIN is a clear, colorless solution free of particulate matter. XEOMIN should not be used if the reconstituted solution has a cloudy appearance or contains floccular or particulate matter.1

Administration instructions1

Important: Do not pry or pop the cap off of the XEOMIN vial, as it is vacuum packed and doing so will result in XEOMIN powder dispersing into the air.

Learn More About the Reconstitution of XEOMIN

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Unopened vials of XEOMIN should be stored at or below 25°C (77°F). Refrigeration of unopened vials is not required. Do not use after the expiration date on the vial. XEOMIN is reconstituted prior to use with sterile, preservative-free 0.9% Sodium Chloride Injection, USP, and may be stored in a refrigerator at 2°C to 8°C (36°F to 46°F) for up to 24 hours until time of use.


  1. XEOMIN® [package insert]. Raleigh, NC: Merz North America, Inc; 2018.