Using XEOMIN® (incobotulinumtoxinA)— Step by Step

Reconstitution and dilution instructions

Prior to injection, reconstitute each vial of XEOMIN with sterile, preservative-free 0.9% Sodium Chloride Injection, USP. A 20-27 gauge short-bevel needle is recommended for reconstitution. Draw up an appropriate amount of preservative-free 0.9% Sodium Chloride Injection, USP into a syringe.1

Step 1: Vial preparation1

Clean the exposed portion of the rubber stopper of the vial with alcohol (70%) prior to insertion of the needle.

Step 2: Saline injection1

After vertical insertion of the needle through the rubber stopper, the vacuum will draw the saline into the vial. Gently inject any remaining saline into the vial to avoid foam formation. If the vacuum does not pull the saline into the vial, then XEOMIN must be discarded.

Step 3: Mixing1

Remove the syringe from the vial and mix XEOMIN with the saline by carefully swirling and inverting/flipping the vial—do not shake vigorously.

Reconstituted XEOMIN is a clear, colorless solution free of particulate matter. XEOMIN should not be used if the reconstituted solution has a cloudy appearance or contains floccular or particulate matter.1

Administration instructions1

  • Intended for intramuscular injection only
  • Should be used for only one injection session and only one patient
  • Number of injection sites depends on size of muscle to be treated and volume of reconstituted XEOMIN injected
  • Reconstituted XEOMIN solution should be administered within 24 hours after dilution. During this time period, reconstituted XEOMIN should be stored in a refrigerator 2° to 8°C (36° to 46°F).

Important: Do not pry or pop the cap off of the XEOMIN vial, as it is vacuum packed and doing so will result in XEOMIN powder dispersing into the air.


Unopened vials of XEOMIN can be stored at room temperature 20° to 25°C (68° to 77° F), in a refrigerator at 2° to 8°C (36° to 46°F), or in a freezer at -20° to -10°C (-4° to 14°F) for up to 36 months. Do not use after the expiration date on the vial. Reconstituted XEOMIN should be stored in a refrigerator at 2° to 8°C (36° to 46°F) and administered within 24 hours.1


  1. XEOMIN® [package insert]. Raleigh, NC: Merz North America, Inc; 2015.