XEOMIN® (incobotulinumtoxinA) Benefits

• Approved in Europe since 2005
• Marketed in 20 countries
• More than 84,000 patients treated worldwide
• Proprietary manufacturing process removes accessory proteins

How supplied

• Available in 50- and 100-unit single-use vials
• 50-unit vial may allow for more precise billing
• 50-unit vial may help reduce waste

Storage

• Unreconstituted XEOMIN is stable for 3 years at temperatures ranging from –20°C to 25°C (–4°F to 77°F)
• Reconstituted XEOMIN is stable for 24 hours at 2°C to 8°C (36°F to 46°F)
• XEOMIN is shipped without dry ice and may be transported between offices without refrigeration
• No styrofoam packing for a greener product footprint

Indications

• XEOMIN® is indicated for the treatment of adults with cervical dystonia to decrease the severity of abnormal head position and neck pain in both botulinum toxin-naïve and previously treated patients.
• XEOMIN is indicated for the treatment of adults with blepharospasm who were previously treated with onabotulinumtoxinA (Botox®).

Demonstrated efficacy

• Significant efficacy vs placebo in the treatment of blepharospasm and cervical dystonia proven in pivotal clinical trials
  • In blepharospasm: In the ITT population, the difference between the XEOMIN group and the placebo group in the change of the Jankovic Rating Scale (JRS) Severity subscore from baseline to Week 6 was –1.0 points (p<0.001)
  • In cervical dystonia: In the ITT population, the difference between the XEOMIN 120-unit group and the placebo group in the change of the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) Total score from baseline to Week 4 was –7.5 points (p<0.001)

Dosing

• The potency units for Xeomin are specific to the preparation and not interchangeable with other botulinum toxin products
• The recommended initial dose of XEOMIN for the treatment of blepharospasm is the same dose as the patient’s previous dose of Botox (onabotulinumtoxinA)
• The recommended initial dose of XEOMIN for cervical dystonia is 120 units
• See the dosing page for additional specific dosing and administration considerations for XEOMIN

Comprehensive physician and patient support

• A single point of contact for assistance with reimbursement, ordering, product information, and patient support
• Drug co-pay assistance available to eligible patients