XEOMIN® (incobotulinumtoxinA) Benefits

Xeomin Benefits

  • Approved in Europe since 2005
  • Marketed in 20 countries
  • More than 84,000 patients treated worldwide
  • Proprietary manufacturing process removes accessory proteins

How supplied

  • Available in 50- and 100-unit single-use vials
  • 50-unit vial may allow for more precise billing
  • 50-unit vial may help reduce waste

Storage

  • Unreconstituted XEOMIN is stable for 3 years at temperatures ranging from –20°C to 25°C (–4°F to 77°F)
  • Reconstituted XEOMIN is stable for 24 hours at 2°C to 8°C (36°F to 46°F)
  • XEOMIN is shipped without dry ice and may be transported between offices without refrigeration
  • No styrofoam packing for a greener product footprint

Indications

  • XEOMIN® is indicated for the treatment of adults with cervical dystonia to decrease the severity of abnormal head position and neck pain in both botulinum toxin-naïve and previously treated patients.
  • XEOMIN is indicated for the treatment of adults with blepharospasm who were previously treated with onabotulinumtoxinA (Botox®).

Demonstrated efficacy

  • Significant efficacy vs placebo in the treatment of blepharospasm and cervical dystonia proven in pivotal clinical trials
    • In blepharospasm: In the ITT population, the difference between the XEOMIN group and the placebo group in the change of the Jankovic Rating Scale (JRS) Severity subscore from baseline to Week 6 was –1.0 points (p<0.001)
    • In cervical dystonia: In the ITT population, the difference between the XEOMIN 120-unit group and the placebo group in the change of the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) Total score from baseline to Week 4 was –7.5 points (p<0.001)

Dosing

  • The potency units for Xeomin are specific to the preparation and not interchangeable with other botulinum toxin products
  • The recommended initial dose of XEOMIN for the treatment of blepharospasm is the same dose as the patient’s previous dose of Botox (onabotulinumtoxinA)
  • The recommended initial dose of XEOMIN for cervical dystonia is 120 units
  • See the dosing page for additional specific dosing and administration considerations for XEOMIN

Comprehensive physician and patient support

  • A single point of contact for assistance with reimbursement, ordering, product information, and patient support
  • Drug co-pay assistance available to eligible patients
the copay assistance program

INDICATIONS AND USAGE

Cervical Dystonia: XEOMIN (incobotulinumtoxinA) is indicated for the treatment of adults with cervical dystonia to decrease the severity of abnormal head position and neck pain in both botulinum toxin-naïve and previously treated patients.

Blepharospasm: XEOMIN (incobotulinumtoxinA) is indicated for the treatment of adults with blepharospasm who were previously treated with onabotulinumtoxinA (Botox).

IMPORTANT SAFETY INFORMATION

WARNING: Distant Spread of Toxin Effect

Postmarketing reports indicate that the effects of XEOMIN and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These may include asthenia, generalized muscle weakness, diplopia, blurred vision, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence and breathing difficulties. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults treated for spasticity and other conditions, particularly in those patients who have underlying conditions that would predispose them to these symptoms. In unapproved uses, including spasticity in children and adults, and in approved indications, cases of spread of effect have been reported at doses comparable to those used to treat cervical dystonia and at lower doses [see Warnings and Precautions (5.1)].

CONTRAINDICATIONS

XEOMIN is contraindicated in patients with a known hypersensitivity to the active substance botulinum toxin type A or to any of the components in the formulation and in the presence of infection at the proposed injection site(s).

WARNINGS AND PRECAUTIONS

  • The potency units of XEOMIN are not interchangeable with other preparations of botulinum toxin products. Therefore, units of biological activity of XEOMIN cannot be compared to or converted into units of any other botulinum toxin products.
  • Hypersensitivity reactions have been reported with botulinum toxin products (anaphylaxis, serum sickness, urticaria, soft tissue edema, and dyspnea). If serious and/or immediate hypersensitivity reactions occur further injection of XEOMIN should be discontinued and appropriate medical therapy immediately instituted.
  • Treatment with XEOMIN and other botulinum toxin products can result in swallowing or breathing difficulties. Patients with pre-existing swallowing or breathing difficulties may be more susceptible to these complications. In most cases, this is a consequence of weakening of muscles in the area of injection that are involved in breathing or swallowing. When distant effects occur, additional respiratory muscles may be involved [See Boxed Warning]. Deaths as a complication of severe dysphagia have been reported after treatment with botulinum toxin. Dysphagia may persist for several months, and require use of a feeding tube to maintain adequate nutrition and hydration. Aspiration may result from severe dysphagia and is a particular risk when treating patients in whom swallowing or respiratory function is already compromised. These reactions can occur within hours to weeks after injection with botulinum toxin.
  • Cervical Dystonia: Patients with smaller neck muscle mass and patients who require bilateral injections into the sternocleidomastoid muscles are at greater risk of dysphagia. Limiting the dose injected into the sternocleidomastoid muscle may decrease the occurrence of dysphagia.
  • Blepharospasm: Injection of XEOMIN into the orbicularis oculi muscle may lead to reduced blinking and corneal exposure with possible ulceration or perforation. Lower lid injections should not be repeated if diplopia occurred with previous botulinum toxin injections.
  • Individuals with peripheral motor neuropathic diseases, amyotrophic lateral sclerosis, or neuromuscular junctional disorders (e.g., myasthenia gravis or Lambert-Eaton syndrome) should be monitored particularly closely when given botulinum toxin. Patients with neuromuscular disorders may be at increased risk of clinically significant effects including severe dysphagia and respiratory compromise from typical doses of XEOMIN.

ADVERSE REACTIONS

Cervical Dystonia: The most commonly observed adverse reactions (incidence ≥10% of patients and twice the rate of placebo) for XEOMIN 120 Units and XEOMIN 240 Units, respectively, were: dysphagia (13%, 18%), neck pain (7%, 15%), muscle weakness (7%, 11%), and musculoskeletal pain (7%, 4%).

Blepharospasm: The most common adverse reactions (incidence ≥10% of patients and twice the rate of placebo) for XEOMIN were eyelid ptosis (19%), dry mouth (16%), visual impairment (12%), diarrhea (8%), and headache (7%).

DRUG INTERACTIONS

Concomitant treatment of XEOMIN and aminoglycoside antibiotics, spectinomycin, or other agents that interfere with neuromuscular transmission (e.g., tubocurarine-like agents), or muscle relaxants, should be observed closely because the effect of XEOMIN may be potentiated.

USE IN PREGNANCY

Pregnancy Category C: There are no adequate and well-controlled studies in pregnant women. XEOMIN should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Please see full Prescribing Information, including Boxed WARNING.

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