Pediatric Patients With Chronic Sialorrhea | XEOMIN®

XEOMIN is the First and Only FDA-Approved Neuromodulator For Pediatric Patients With Chronic Sialorrhea

Two principal types1:

  • Anterior sialorrhea: forward spillage of saliva from the mouth
  • Posterior sialorrhea: backward spillage of saliva from mouth down airway

Causes2

  • Cerebral Palsy (CP)
  • Traumatic Brain Injury
  • Epilepsy
  • Congenital abnormality of brain development
Jacob, pediatric patient with chronic sialorrhea treated with XEOMIN®

Jacob,* an adolescent patient with chronic sialorrhea treated with XEOMIN

*Images are for illustration only. Not an actual patient.

An estimated 445,000 children under the age of 18 suffer from chronic sialorrhea.1,3

Complications That Develop as a Result of Chronic Sialorrhea

Signs, symptoms, and effects of Sialorrhea. Pinch to zoom

Symptoms4

  • Excessive wetness
  • Skin breakdown around the mouth
  • Infection from skin breakdown
  • Dehydration or not enough fluids
  • Foul odor

Impact on Daily Living5-10

Social:

  • Embarrassment
  • Social isolation
  • Stigmatization

Medical:

  • Perioral skin breakdown
  • Aspiration pneumonia
  • Choking
  • Dehydration

References

  1. Fairhurst CB, Cockerill H. Management of drooling in children. Arch Dis Child Educ PractEd 2011;96:25-30
  2. LakrajAA, MoghimiN, Jabbari B. Sialorrhea: anatomy, pathophysiology and treatment with emphasis on the role ofbotulinum toxins. Toxins (Basel). 2013;5(5):1010-1031.
  3. Cerebralpalsy.org. Accessed November 19, 2020.
  4. Hockstein NG, Samadi DS, Gendron K, Handler SD. Sialorrhea: a management challenge. Am Fam Physician. 2004;69(11):2628–2634.
  5. Kalf JG et al. J Neurol 2007;254:1227–32.
  6. Leibner J et al. Parkinsonism Relat Disord 2010;16:475–7.
  7. Ou R et al. Parkinsonism Relat Disord 2015;21:211–5.
  8. Schirinzi T et al. Clin Neurol Neurosurg 2017;156:63–5.
  9. Banfi P et al. Respir Care 2015;60:446–54.
  10. El-Hakim H et al. Arch Otolaryngol Head Neck Surg 2008;134:470–4.