Using XEOMIN Step by Step

XEOMIN Offers Convenience for Your Practice

XEOMIN® offered in 3 different vial options.

Offered in 3 different vial options:
50, 100, 200 Units1

Packaged to help minimize waste.

Packaged to help
minimize waste

Does not require refrigeration.

Does not require refrigeration
prior to reconstitution1

Reconstitution and Dilution—Flip It. Don't Shake It.

  • Prior to injection, reconstitute each vial of XEOMIN with sterile, preservative-free 0.9% Sodium Chloride Injection, USP1
    • A 20- to 27-gauge short-bevel needle is recommended for reconstitution
  • Draw up an appropriate amount of preservative-free 0.9% Sodium Chloride Injection, USP into a syringe1
Reconstitution and Dilution Instructions: vial preparation

Step 1: Vial preparation

Clean the exposed portion of the
rubber stopper of the vial with
alcohol (70%) prior to insertion
of the needle.1

Reconstitution and Dilution Instructions: saline injection

Step 2: Saline injection

After vertical insertion of the needle
through the rubber stopper, the
vacuum will draw the saline into the
vial. Gently inject any remaining
saline into the vial to avoid foam
formation. If the vacuum does not
pull the saline into the vial, then
XEOMIN must be discarded.1

Reconstitution and Dilution Instructions: mixing

Step 3: Mixing

Remove the syringe from the vial and
mix XEOMIN with the saline by carefully
swirling and inverting/flipping the vial
—do not shake vigorously.1

XEOMIN Reconstitution Video

Reconstituted XEOMIN is a clear, colorless solution free of particulate matter. XEOMIN should not be used if the reconstituted solution has a cloudy appearance or contains floccular or particulate matter.1

Refrigeration is not required.

Storage—No Refrigeration Required1

  • Refrigeration of unopened vials is not required
  • Unopened vials of XEOMIN should be stored at or below 25°C (77°F)
  • Do not use after the expiration date on the vial
  • Reconstituted XEOMIN may be stored in a refrigerator at 2° to 8°C (36° to 46°F) for up to 24 hours until time of use

Administration Instructions1

  • Intended for intramuscular or intra-salivary gland injection only
  • Should be used for only 1 injection session and only 1 patient
  • For intramuscular injections, the number of injection sites is dependent upon size of muscle to be treated and volume of reconstituted XEOMIN injected. A suitable sterile needle (eg, 27–30 gauge [0.30–0.40 mm diameter], 12.5 mm length) should be used for intra-salivary gland administration for the treatment of chronic sialorrhea
  • The salivary glands can be located using ultrasound imaging or surface anatomical landmarks
  • Reconstituted XEOMIN solution should be administered within 24 hours after dilution. During this time period, reconstituted XEOMIN should be stored in a refrigerator at 2° to 8°C (36° to 46°F)

Important: Do not pry or pop the cap off of the XEOMIN vial, as it is vacuum packed and doing so will result in XEOMIN powder dispersing into the air.


  1. XEOMIN® [Package insert]. Raleigh, NC: Merz Pharmaceuticals, LLC; 2019.