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XEOMIN® - Frequently Asked Questions

Frequently Asked Questions About XEOMIN

What is XEOMIN?

XEOMIN (zeo-min) is a prescription neuromodulator that is injected into muscles or glands and used to treat adults with blepharospasm, upper limb spasticity, cervical dystonia, and chronic sialorrhea.1 The FDA approved XEOMIN in 2018 for use in adults with chronic sialorrhea, 2015 in adults with upper limb spasticty, and 2010 in adults with cervical dystonia and blepharospasm (who have been previously treated with Botox). In 2019, XEOMIN was approved for use in adults with blepharospasm who had not previously been treated with Botox. The active ingredient in XEOMIN is a type of botulinum toxin called incobotulinumtoxinA.1

What conditions does XEOMIN treat?

XEOMIN is a unique, first-line treatment option that is FDA-approved for adults with upper limb spasticity, cervical dystonia, blepharospasm, and chronic sialorrhea.1


If you are already receiving therapy for one of these indications, speak with your doctor to see if XEOMIN may be right for you.

How is XEOMIN made?

Merz, the maker of XEOMIN, used XTRACT TechnologyTM. This is the only state-of-the-art manufacturing process that uniquely purifies the molecule removing the unnecessary proteins, leaving just the active therapeutic component. The direct impact of the non-therapeutic proteins on long term safety or efficacy has not been established. Information about the unique XEOMIN manufacturing process and the properties of incobotulinumtoxinA is not intended to imply superiority over other botulinum toxin type A products.

What is botulinum toxin type A?

Botulinum toxin type A is a neuromodulator used to treat the symptoms of adults with upper limb spasticity, cervical dystonia, blepharospasm, and chronic sialorrhea.1 When injected into muscles or glands, this neuromodulator helps by blocking signals from the nerves that can cause the muscles to spasm, or blocking excessive production of saliva in the salivary gland.1

How is XEOMIN given?

XEOMIN is injected directly into the affected muscles or glands. Your doctor will decide how many places need to be injected and the dose per location. For most people, the first effects of XEOMIN are typically seen within 7 days. The effects of XEOMIN usually last about 12 weeks, but may last significantly longer or shorter in individual patients.1 Read the Medication Guide to learn more about what to expect from treatment with XEOMIN.


Everyone is different, so you should talk to your doctor if you have any questions or concerns about your treatment process.1

What are the most common side effects of XEOMIN?

The most common side effects of XEOMIN in people with upper limb spasticity include1:

  • seizure

  • nasal congestion, sore throat, runny nose

  • dry mouth

  • upper respiratory infection

The most common side effects of XEOMIN in people with cervical dystonia include1:

  • difficulty swallowing

  • neck pain

  • muscle weakness

  • pain at the injection site

  • muscle and bone pain

The most common side effects of XEOMIN in people with blepharospasm include1:

  • drooping of the eyelid

  • dry eye

  • vision problems

  • dry mouth

The most common side effects of XEOMIN in people with chronic sialorrhea include1:

  • needing to have a tooth pulled (extracted)

  • dry mouth

  • diarrhea

  • high blood pressure

XEOMIN may cause serious side effects that can be life-threatening. Call your doctor or get medical help right away if you have any of these problems anytime (hours to week) after treatment with XEOMIN:

  • Problems with swallowing, speaking, or breathing can happen within hours to weeks after an injection of XEOMIN if the muscles that you use to breathe and swallow become weak. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment with XEOMIN.

  • People with certain breathing problems may need to use muscles in their neck to help them breathe and may be at greater risk for serious breathing problems with XEOMIN.

  • Swallowing problems may last for several months, and during that time you may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving XEOMIN have the highest risk of getting these problems.

  • Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, and trouble swallowing.


Please see full Prescribing Information and Medication Guide for a full description of serious side effects.

What type of financial assistance is available?

Once you and your doctor have decided XEOMIN is right for you, MERZ CONNECT offers you savings and support to help you get started and stay on therapy.*

For commercially insured patients who are eligible, Merz will reimburse out-of-pocket XEOMIN medication costs and related administration fees not covered by insurance, up to $5,000 every 12 months.* Eligible commercially insured patients may pay as little as $0 out of pocket with the XEOMIN Patient Savings Program.*†

Learn more about the eligibility criteria.

*Restrictions apply to eligibility. Commercial Insurance required. Reimbursement limited to out-of-pocket XEOMIN medication costs and related administration fees. State limitations may apply. Please see Full Terms and Conditions at XEOMIN.com. Merz reserves the right to change XEOMIN Patient Savings Program Terms and Conditions, including the eligibility requirements, at any time. This is not health insurance.

You may be required to pay upfront for your co-pay/co-insurance, as determined by your insurance coverage/policy and your healthcare provider’s co-pay collection practice.

References

1.  XEOMIN® [Package insert]. Raleigh, NC: Merz Pharmaceuticals, LLC; 2019.