Frequently Asked Questions About XEOMIN® (incobotulinumtoxinA)

What is XEOMIN?

XEOMIN (zeo-min) is a prescription neurotoxin medicine that is injected into muscles or glands and used to treat adults with blepharospasm (who have been previously treat with Botox® [onabotulinumtoxinA]), upper limb spasticity, cervical dystonia, and chronic sialorrhea.1 The FDA approved XEOMIN in 2018 for use in adults with chronic sialorrhea, 2015 in adults with upper limb spasticty; and 2010 in adults with cervical dystonia and blepharospasm (who have been previously treated with Botox® [onabotulinumtoxinA].1 The active ingredient in XEOMIN is a type of botulinum toxin called incobotulinumtoxinA.1

Where is XEOMIN approved?

XEOMIN has been FDA approved for use in the United States in adults with cervical dystonia or blepharospasm since 2010, for the treatment of upper limb spasticity in adults since 2015, and for chronic sialorrhea in adults since 2018.1 XEOMIN is currently available in 67 countries worldwide.2 More than 2.5 million adults patients around the world have been treated with XEOMIN for various therapies.2

Who is XEOMIN for?

XEOMIN is a prescription medicine used in adults:

  • that is injected into glands that make saliva and is used to treat adults with long-lasting (chronic) drooling (sialorrhea)

  • that is injected into muscles and used to:

    • treat increased muscle stiffness in the arm because of adults with upper limb spasticity

    • treat the abnormal head position and neck pain for adults with cervical dystonia (CD) who have and have not had prior treatment with botulinum toxin

    • treat abnormal spasm of the eyelids in adults with blepharospasm who have had prior treatment with Botox® [onabotulinumtoxinA]

How is XEOMIN made?

Merz, the maker of XEOMIN, uses a proprietary manufacturing process to remove accessory proteins from botulinum toxin type A. The clinical significance of the absence or presence of accessory proteins, including any impact on safety or efficacy, has not been established. This information about the XEOMIN manufacturing process and the properties of incobotulinumtoxinA is not intended to imply superiority over other botulinum toxin A products.

What is botulinum toxin type A?

Botulinum toxin type A is a neurotoxin used to treat the symptoms of adults with upper limb spasticity, cervical dystonia, blepharospasm, and chronic sialorrhea.1 When injected into muscles or glands, this neurotoxin helps by blocking signals from the nerves that can cause the muscles to spasm, or blocking excessive production of saliva in the salivary gland.1

Can I switch to XEOMIN from my existing therapy for adults with upper limb spasticity, adults with cervical dystonia, adults with blepharospasm, or adults with chronic sialorrhea?

Discuss your current treatment option with your doctor to see if switching to XEOMIN is right for you.

How is XEOMIN given?

XEOMIN is injected directly into the affected muscles or glands. Your doctor will decide how many places need to be injected and the dose per location. For most people, the first effects of XEOMIN are typically seen within 7 days. Everyone is different, so you should talk to your doctor if you have any questions or concerns about your treatment process.1

How often will I need treatment with XEOMIN?

The effects of XEOMIN usually last about 12 weeks, but may last significantly longer or shorter in individual patients.1 Read more about what to expect from treatment with XEOMIN.

What are the most common side effects of XEOMIN?

The most common side effects of XEOMIN in people with upper limb spasticity include:

  • seizure

  • nasal congestion, sore throat, runny nose

  • dry mouth

  • upper respiratory infection

The most common side effects of XEOMIN in people with cervical dystonia include:

  • difficulty swallowing

  • neck pain

  • muscle weakness

  • pain at the injection site

  • muscle and bone pain

The most common side effects of XEOMIN in people with blepharospasm include:

  • drooping of the eyelid

  • dry eye

  • dry mouth

  • diarrhea

  • headache

  • vision problems

  • shortness of breath

  • nasal congestion, sore throat and runny nose

  • respiratory infection

The most common side effects of XEOMIN in people with chronic sialorrhea include:

  • needing to have a tooth pulled (extracted)

  • dry mouth

  • diarrhea

  • high blood pressure

XEOMIN may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems anytime (hours to week) after treatment with XEOMIN®:

  • Problems with swallowing, speaking, or breathing can happen within hours to weeks after an injection of XEOMIN if the muscles that you use to breathe and swallow become weak. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment with XEOMIN.

  • People with certain breathing problems may need to use muscles in their neck to help them breathe and may be at greater risk for serious breathing problems with XEOMIN.

  • Swallowing problems may last for several months, and during that time you may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving XEOMIN have the highest risk of getting these problems.

  • Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.

Please see full Prescribing Information and Medication Guide for a full description of serious side effects.

What type of financial assistance is available?

As part of our commitment to patients, Merz, the maker of XEOMIN, created the XEOMIN Patient Savings Program and the XEOMIN Patient Assistance Program.

XEOMIN Patient Savings Program: If you are eligible to enroll in this program, Merz will directly reimburse you for your eligible out-of-pocket costs for medication and related administration fees. Learn more about the eligibility criteria.

XEOMIN Patient Assistance Program: If you are eligible to enroll in this program, Merz will provide XEOMIN at no charge. Learn more about the eligibility criteria.

Where can I get more information about XEOMIN?

Ask your doctor about XEOMIN; only your doctor can offer information that is specific to your own health history. You can also learn more by signing up for the My XEOMIN Kit and reading the full Prescribing Information and Medication Guide for XEOMIN.

References

1.  XEOMIN® [package insert]. Raleigh, NC: Merz North America, Inc; 2018.

2.  Data on file. Raleigh, NC: Merz Pharmaceuticals, LLC.