XEOMIN (zeo-min) is a prescription neuromodulator that is injected into muscles or glands and used to treat adults with blepharospasm, upper limb spasticity, cervical dystonia, and chronic sialorrhea.1 The FDA approved XEOMIN in 2018 for use in adults with chronic sialorrhea, 2015 in adults with upper limb spasticty, and 2010 in adults with cervical dystonia and blepharospasm (who have been previously treated with Botox). In 2019, XEOMIN was approved for use in adults with blepharospasm who had not previously been treated with Botox. The active ingredient in XEOMIN is a type of botulinum toxin called incobotulinumtoxinA.1
XEOMIN is a unique, first-line treatment option that is FDA-approved for adults with upper limb spasticity, cervical dystonia, blepharospasm, and chronic sialorrhea.1
If you are already receiving therapy for one of these indications, speak with your doctor to see if XEOMIN may be right for you.
Merz, the maker of XEOMIN, used XTRACT TechnologyTM. This is the only state-of-the-art manufacturing process that uniquely purifies the molecule removing the unnecessary proteins, leaving just the active therapeutic component. The direct impact of the non-therapeutic proteins on long term safety or efficacy has not been established. Information about the unique XEOMIN manufacturing process and the properties of incobotulinumtoxinA is not intended to imply superiority over other botulinum toxin type A products.
Botulinum toxin type A is a neuromodulator used to treat the symptoms of adults with upper limb spasticity, cervical dystonia, blepharospasm, and chronic sialorrhea.1 When injected into muscles or glands, this neuromodulator helps by blocking signals from the nerves that can cause the muscles to spasm, or blocking excessive production of saliva in the salivary gland.1
XEOMIN is injected directly into the affected muscles or glands. Your doctor will decide how many places need to be injected and the dose per location. For most people, the first effects of XEOMIN are typically seen within 7 days. The effects of XEOMIN usually last about 12 weeks, but may last significantly longer or shorter in individual patients.1 Read the Medication Guide to learn more about what to expect from treatment with XEOMIN.
Everyone is different, so you should talk to your doctor if you have any questions or concerns about your treatment process.1
The most common side effects of XEOMIN in people with upper limb spasticity include1:
nasal congestion, sore throat, runny nose
upper respiratory infection
The most common side effects of XEOMIN in people with cervical dystonia include1:
pain at the injection site
muscle and bone pain
The most common side effects of XEOMIN in people with blepharospasm include1:
drooping of the eyelid
The most common side effects of XEOMIN in people with chronic sialorrhea include1:
needing to have a tooth pulled (extracted)
high blood pressure
XEOMIN may cause serious side effects that can be life-threatening. Call your doctor or get medical help right away if you have any of these problems anytime (hours to week) after treatment with XEOMIN:
Problems with swallowing, speaking, or breathing can happen within hours to weeks after an injection of XEOMIN if the muscles that you use to breathe and swallow become weak. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment with XEOMIN.
People with certain breathing problems may need to use muscles in their neck to help them breathe and may be at greater risk for serious breathing problems with XEOMIN.
Swallowing problems may last for several months, and during that time you may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving XEOMIN have the highest risk of getting these problems.
Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, and trouble swallowing.
Once you and your doctor have decided XEOMIN is right for you, MERZ CONNECT™ offers you savings and support to help you get started and stay on therapy.*
For commercially insured patients who are eligible, Merz will reimburse out-of-pocket XEOMIN medication costs and related administration fees not covered by insurance, up to $5,000 every 12 months.* Eligible commercially insured patients may pay as little as $0 out of pocket with the XEOMIN Patient Savings Program.*†
Learn more about the eligibility criteria.
*Restrictions apply to eligibility. Commercial Insurance required. Reimbursement limited to out-of-pocket XEOMIN medication costs and related administration fees. State limitations may apply. Please see Full Terms and Conditions at XEOMIN.com. Merz reserves the right to change XEOMIN Patient Savings Program Terms and Conditions, including the eligibility requirements, at any time. This is not health insurance.
†You may be required to pay upfront for your co-pay/co-insurance, as determined by your insurance coverage/policy and your healthcare provider’s co-pay collection practice.
1. XEOMIN® [Package insert]. Raleigh, NC: Merz Pharmaceuticals, LLC; 2019.
Read the Medication Guide before you start receiving XEOMIN® (Zeo-min) and each time XEOMIN is given to you as there may be new information. The risk information provided here is not comprehensive. To learn more:
XEOMIN is a prescription medicine used in adults:
It is not known if XEOMIN is safe and effective in children under 18 years of age.
XEOMIN may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems anytime (hours to weeks) after treatment with XEOMIN:
These symptoms can happen hours to weeks after you receive an injection of XEOMIN. These problems could make it unsafe for you to drive a car or do other dangerous activities.
Do not take XEOMIN if you: are allergic to XEOMIN or any of the ingredients in XEOMIN (see the end of this Guide for a list of ingredients in XEOMIN), had an allergic reaction to any other botulinum toxin product such as rimabotulinumtoxinB (Myobloc®), onabotulinumtoxinA (Botox®, Botox® Cosmetic), or abobotulinumtoxinA (Dysport®) or have a skin infection at the planned injection site.
Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Talk to your doctor before you take any new medicines after you receive XEOMIN.
Using XEOMIN with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your doctor that you have received XEOMIN in the past. Especially tell your doctor if you:
Ask your doctor if you are not sure if your medicine is one that is listed above.
Know the medicines you take. Keep a list of your medicines with you to show your doctor and pharmacist each time you get a new medicine.
XEOMIN can cause serious side effects including:
The most common side effects of XEOMIN in people with chronic sialorrhea include:
The most common side effects of XEOMIN in people with upper limb spasticity include:
The most common side effects of XEOMIN in people with cervical dystonia include:
The most common side effects of XEOMIN in people with blepharospasm include:
These are not all the possible side effects of XEOMIN.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. You can ask your pharmacist or doctor for information about XEOMIN that is written for health professionals.
Active Ingredients: botulinum toxin type A
Inactive Ingredients: human albumin and sucrose