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XEOMIN® - Chronic Sialorrhea Signs and Symptoms

Adults With Chronic Sialorrhea

Disease
Overview
Clinical
Trial
Efficacy Safety Dosing

XEOMIN is the first and only FDA-approved botulinum toxin type A for adults with chronic sialorrhea, a secondary symptom that impacts an estimated 600,000 adults in the United States1-7

Adults with chronic sialorrhea may experience some or all of the symptoms below8:

These symptoms may have an impact on activities of daily living, including4:

Colin, adult patient with chronic sialorrhea treated with Xeomin
Sialorrhea Symptoms

Sialorrhea (drooling or excessive salivation) is a common problem in the neurologically impaired (ie, those with mental retardation or cerebral palsy) and in those who have Parkinson’s disease or have had a stroke. It is most commonly caused by poor oral and facial muscle control.2

References

  1. Kowal SL, Dall TM, Chakrabarti R, Storm MV, Jain A. The current and projected economic burden of Parkinson’s disease in the United States. Movement Disord. 2013;28(3):311-318.
  2. Kalf JG, de Swart BJ, Borm GF, Bloem BR, Munneke M. Prevalence and definition of drooling in Parkinson’s disease: a systematic review. J Neurol. 2009;256(9):1391-1396.
  3. Prevalence and most common causes of disability among adults – United States, 2005. Centers for Disease Control website. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5816a2.htm. Accessed June 27, 2019.
  4. Walshe M, Smith M, Pennington L. Interventions for drooling in children with cerebral palsy. Cochrane Database Syst Rev. 2012;11:CD008624.
  5. Tiigimäe-Saar J, Taba P, Tamme T. Does Botulinum neurotoxin type A treatment for sialorrhea change oral health? Clin Oral Invest. 2017;21(3):795-800.
  6. What is ALS? ALS Association website: http://www.alsa.org/news/public-awareness/als-awareness-month/2016/what-is-als.html. Accessed June 27, 2019.
  7. XEOMIN® [Package insert]. Raleigh, NC: Merz Pharmaceuticals, LLC; 2019.
  8. Hockstein NG, Samadi DS, Gendron K, Handler SD. Sialorrhea: a management challenge. Am Fam Physician. 2004;69(11):2628-2634.