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Reconstitution, Dilution and Storage - XEOMIN®

Using XEOMIN Step by Step

XEOMIN Offers Convenience for Your Practice

With multiple vial sizes for ease of dosing, no need for refrigeration prior to reconstitution, and simplified packaging, XEOMIN offers convenience for you and your practice.

Icon displaying a tiny vile with a health plus cross sign in the center

Offered in 3 different vial options:
50, 100, 200 units1

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Packaged to help
minimize waste

Refrigeration Icon with temperature probe over dark background

Does not require refrigeration
prior to reconstitution1

Reconstitution and Dilution Instructions: Flip It. Don't Shake It.

Prior to injection, reconstitute each vial of XEOMIN with sterile, preservative-free 0.9% Sodium Chloride Injection, USP. A 20- to 27-gauge short-bevel needle is recommended for reconstitution. Draw up an appropriate amount of preservative-free 0.9% Sodium Chloride Injection, USP into a syringe.1

Reconstitution and Dilution Instructions: vial preparation

Step 1: Vial preparation1

Clean the exposed portion of the rubber stopper of the vial with alcohol (70%) prior to insertion of the needle.

Reconstitution and Dilution Instructions: saline injection

Step 2: Saline injection1

After vertical insertion of the needle through the rubber stopper, the vacuum will draw the saline into the vial. Gently inject any remaining saline into the vial to avoid foam formation. If the vacuum does not pull the saline into the vial, then XEOMIN must be discarded.

Reconstitution and Dilution Instructions: mixing

Step 3: Mixing1

Remove the syringe from the vial and mix XEOMIN with the saline by carefully swirling and inverting/flipping the vial—do not shake vigorously.

Reconstituted XEOMIN is a clear, colorless solution free of particulate matter. XEOMIN should not be used if the reconstituted solution has a cloudy appearance or contains floccular or particulate matter.1

Storage — No Refrigeration Required1

Diluent volumes for XEOMIN reconstitution

Administration instructions1

Important: Do not pry or pop the cap off of the XEOMIN vial, as it is vacuum packed and doing so will result in XEOMIN powder dispersing into the air.


  1. XEOMIN® [Package insert]. Raleigh, NC: Merz Pharmaceuticals, LLC; 2019.